The Centers for Disease Control (CDC) / National Center for Immunization and Respiratory Diseases (NCIRD)/ Division of Bacterial Diseases (DBD), Respiratory Diseases Branch (RDB) intends to award a sole source firm fixed price Purchase Order to New England Biolabs of Ipswich, MA, for the acquisition of Bst 2.0 WarmStart DNA Polymerase. New England Biolabs is the only contractor that provides a strand-displacing polymerase with a reversibly-bound aptamer that inhibits polymerase activity below 45°C.The Bst 2.0 polymerase has an aptamer that reversibly binds to the enzyme, inhibiting activity below 45°C, i.e. during reaction assembly at room temperature. This binding event ensures that non-specific amplification events do not occur at permissive lower temperatures during set-up. Additionally, this enzyme enables rapid amplification of nucleic acid under isothermal conditions and is an essential component of point-of-care assays in development. In experiments, CDC researchers have shown that the Bst 2.0 form of the enzyme, designed in silico by New England Biolabs, amplifies target more rapidly and sensitively than other strand-displacing enzymes that do not possess the "warm start" feature.

This Procurement is for a Commercial Item as defined by FAR Parts 2 & 12.

This contract action is for supplies or services for which the Government intends to solicit and negotiate with only one source under the authority of FAR 13.106-1(b) (SAP) and 10 U.S.C. 2304(c)(1)

This notice of intent is not a request for competitive quotations; however, all quotations/responses received within 15 business days of the issuance of this notice will be considered by the government.

A determination by the government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the government. Information received will normally be considered solely for the purpose of determining whether to conduct a competitive procurement.

Any quotation/response must be emailed to Florence Black at [email protected] before 08/28/2014 at 11:00 AM.

 

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