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The National Institute of Digestive, Diabetes & Kidney Diseases's (NIDDK Synthetic Bioactive Molecules Section of the Laboratory of Bioorganic Chemistry is involved in the discovery and development of new molecules with medicinal value or for applications to diagnostics. Some of these molecules have the potential to become therapeutics or to be used as important components in diagnostic applications that signal the presence of disease. Applications in either area are of great benefit to human health and thus to NIDDK's mission. Research conducted in the Laboratory of Bioorganic Chemistry involves synthesis of biologically active molecules called peptide nucleic acids (PNAs). This purchase requisition is urgently needed to obtain instrumentation required to prepare sample PNAs for subsequent studies. Each PNA must be able to recognize and bind its DNA or RNA target nucleic acid sequence, and without this instrumentation the NIDDK cannot continue its research on the properties of PNA.
The specs are as follows:
V-10 Touch System Single sample evaporator includes:
-High rotational speed vial drive motor provides a film of sample and eliminates bumping
-Touch screen user interface with pre-programmed evaporation methods optimized for volatile, aqueous and high boiling point solvents. Key parameters are may be user modified
-IR temperature sensor to monitor and control sample temperature during evaporation preventing sample overheating
-Automatic end-of-run detection; stops system and unloads vial -2 mBar, 3-stage, oil free, chemically resistant vacuum pump
-Automated valve for external high vacuum pump
-Adapters to run approved 20 ml & 4 ml vials
V-10 Touch Solvent Manager Upgrade Includes pump, mounting hardware, fittings, software,
and testing to add solvent management capabilities to V-10 touch systems. This retro-fit upgrade includes:
-Sample pump for feed-in capability of larger sample volumes (up to 500 ml)
-Tubing and adapters
-Mounting hardware
-Software
V-10 Automation Upgrade Facilitates the automated introduction of vials to the V-10 Touch. Capacity is 16 samples. Carousel Vial holders, (part numbers 411181, 411182, or 411183) must be ordered separately. Upgrade includes:
-Carousel unit
-Control software
-Mounting hardware
-Connections
First Year Maintenance Package Priority - V-10 Evaporator Installation and operational verification and first year warranty package for Biotage® V-10 Touch rapid solvent evaporator system. Package includes installation, priority response time and 1 preventive maintenance visit during final three months of warranty period.
The Biotage V-10 is needed to interface with the existing HPLC and mass spectrometers in the lab. The V-10 must be able to concentrate multiple samples sequentially and with automation, and also use 3-way drying with a combination of heat, vacuum, and vial rotation to speed solvent removal. In the light of the NIDDK's ongoing studies, consistency and continuity of research goals requires the utilization of BIOTAGE, INC for the requisite products.
The proposed contract action is for supplies or services for which the Government intends to solicit and negotiate with only one source under authority of the 41 U.S.C. 253(c) (1), FAR 6.302. Only one responsible source and no other supplies or services will satisfy agency requirements.
The offeror must include a completed copy of the provision of FAR Clause 52.212-3, Offeror Representations and Certifications - Commercial Items with its offer. The provisions of FAR Clause 52.212-1 Instructions to Offerors - Commercial Items; FAR Clause 52.212-2, Evaluation - Commercial Items; FAR Clause 52.212-4, Contract Terms and Conditions - Commercial Items; and FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial Items - Deviation for Simplified Acquisitions applies to this acquisition. The offeror must include their Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. The clauses are available in full text at http://www.acquisition.gov/far/. Interested vendors capable of furnishing the government with the services specified in this synopsis should submit a copy of their quotation to the below address or via email to [email protected]. Offers must also be accompanied by descriptive literature, delivery timeframe, warranties and/or other information that demonstrates that the offer meets all the foregoing requirements. Quotations will be due on or before August 14, 2017 by 10 am, EST. via email or postal mail. The quotation must reference "Solicitation number" NIH-NIDDK-17-221. Quotations sent by postal mail or other mailing services must be submitted to the following address: Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6710B Rockledge Drive, Room 1159A, Bethesda, MD 20817. Attention: Amber Harris, by the date and time mentioned above. Any questions must be sent via email to [email protected] and must include solicitation#NIH-NIDDK-17-221 in the subject line of email. Faxed copies/responses will not be accepted.
PLEASE NOTE: In order to receive an award, contractor must be registered for "All Awards" and have a valid certification in the System for Award Management (SAM) database at http://www.sam.gov.