THIS IS FOR MARKET RESEARCH PURPOSES ONLY, NOT A REQUEST FOR QUOTE OR SOLICITATION. The Food and Drug Administration, Jefferson Laboratories, in Jefferson, Arkansas, is seeking business sources, including service-disabled veteran-owned small businesses, HUBZone small businesses, and 8(a) certified companies. The following information is provided to assist the FDA in conducting Market Research to identify potential contractors for this effort: The government is looking for sources to provide transgenic mice (both Male and Female) genetically engineered to over express two separate genes associated with Alzheimer’s disease. The mice should over express the amyloid precursor protein (APP) and the gamma secreatase enzyme which cleaves the APP to its toxic AB fragment. By expressing these double mutations, the animal closely mimics the human condition of the disease. The associated North American Industry Classification System (NAICS) Code is-541711- Research and Development in Biotechnology; Small Business Size Standard is 500 employees. Potential contractors must indicate business size and proof of any set-aside certification and provide a contact name, the mailing address, phone number and email address of point of contact. Capability statements must provide enough information to determine if the company can meet the requirement. Interested Contractors must respond with capability statements which are due in person, by postal mail, fax or email to the point of contact listed below on or before Thursday February 19, 2009 by 13:00 hours (Central Time in Jefferson, Arkansas) at the Food and Drug Administration, OC/OSS/OFFAS, Attn: Nick Sartain, 3900 NCTR Road, HFT-320, Jefferson, AR 72079-9502. Reference FDA1053870. For information regarding this market survey, please contact Nick Sartain at (870) 543-7370, FAX (870) 543-7990 or email [email protected].

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