Short Title: Tissue sample and data preparation for Sherlock-Lung study among non-smoking Asian female adenocarcinoma cases in Taiwan
Document Type: Notice of Intent
Solicitation Number: 75N91019R00036
Posted Date: 8/6/2019
Response Date: 8/16/2019
Classification Code: B - Special Studies and Analyses - Not R&D
NAICS Code: 541990 - All Other Professional, Scientific and Technical Services

Contracting Office Address

Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E232 Bethesda, MD 20892, UNITED STATES

Description

The NCI is conducting a whole-genome sequencing study of lung adenocarcinoma tumors from never-smoking women in Asia to identify exposure-related mutational signatures to extend its findings and will compare results with signatures identified in cases it is analyzing from other parts of China, Asia, the West, and other regions as part of the Sherlock-Lung study.

To achieve the goal of Sherlock-Lung study, it's critical to collect fresh-frozen tumor and normal tissues, blood samples and data from non-smoking female lung cancer cases. The Contractor will obtain samples from frozen fresh tumor tissue and adjacent normal lung tissue, matched blood sample, accompanying H and E diagnostic slide and copy of CT report, pathology report and questionnaire data from interview.

This acquisition will be processed under FAR Part 12 - Acquisition for Commercial items and will be made pursuant to the authority in FAR 13.106-1(b)(1) using simplified acquisition procedures for commercial items. The North American Industry Classification System code is 541990 and the business size standard is $15,000,000.

Only one award will be made as a result of this solicitation. This will be awarded as a Non-Severable firm fixed price type contract.

It has been determined there are no opportunities to acquire green products or services for this procurement.

The Contractor shall perform the following tasks for 298 non-smoking lung cancer adenocarcinoma cases with fresh-frozen tumor tissue and adjacent normal tissue samples from these 298 cases enrolled in Taiwan:

1.1 Evaluate the tumor tissue by H and E staining method to determine the percentage of tumor cells.
1.2 Cut fresh-frozen tumor tissue with at least 50% tumor from each lung cancer case and store it in 1.8ml sterile cryovials.
1.3 Cut fresh-frozen normal lung tissue from each lung cancer case and store it in 1.8ml sterile cryovials
1.4 If there are blood sample available, prepare an aliquot of at least 1 ml of whole blood or a buffy coat sample derived from at least 1 ml of whole blood, or at least 2 ug of DNA derived from a buffy coat sample.
1.5 Provide a H and E diagnostic slide or a photomicrograph of the slide from each case, a copy of CT report and pathology report.
1.6 Fresh-frozen tissues should be shipped on dry ice to the laboratory designated by the NCI. H&E diagnostic slides should be shipped on room temperature.
1.7 Fill out a study subject log in Excel file format that will be provided by NCI that will include date of diagnosis, type of procedure used to obtain the sample, and age of study subject, by the end of the period of performance.
1.8 Selected questionnaire variables will be sent to NCI to be used to in the data analysis including variables related to indoor and outdoor air pollution, family history, and other known or suspected risk factors for lung cancer in never smokers in Taiwan.
1.9 Shipping charges must be included in the quote. NCI will not be responsible in the event
charges are not included in the quote.

The period of performance shall be for 12 months from September 15, 2019 to
September 14, 2020.

Note: NCI plans to award a contract that has FOB origin delivery terms.

National Health Research Institutes is the largest institute on health research in Taiwan. The institute is well-qualified in all aspects required for the completion of this contract and has unique staff and experience that are necessary to carry out the terms of this procurement. Further, the National Health Research Institutes has previously successfully provided FFPE tumor tissue samples from cases for NCI lung cancer studies and it is critical that this contractor provide additional frozen tumor samples from the exact same cases so that there will be scientific comparability between the previous and new samples (HHSN261201400640P) necessary to maintain consistency.

This notice is not a request for competitive quotation. However, if any interested party, especially small businesses, believes it can meet the above requirement, it may submit a capability statement, proposal, or quotation, which shall be considered by the agency. The statement of capabilities and any other information furnished must be in writing and must contain material in sufficient detail to allow NCI to determine if the party can perform the requirement. Responses must be received in the contracting office by 12:00 PM EST, on August 16, 2019. All responses and questions must be in writing and faxed 240-276-5401 or emailed to David Romley, Contract Specialist OR via electronic mail at [email protected]. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls will be accepted. In order to receive an award, contractors must be registered and have valid certification in the System for Award Management (SAM) through sam.gov. Reference: 75N91019R00036 on all correspondence.