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Section 8(b) of the Toxic Substances Control Act (TSCA) requires the Environmental Protection Agency (EPA) to compile, keep current, and publish a listing of commercial chemicals existing in U.S. commerce. Accordingly, in 1979 EPA compiled the TSCA Chemical Substance Inventory (Inventory), based on information reported to the Agency under the Inventory Reporting Regulations (40 CFR 710). Since 1979, EPA has been continually updating and publishing the Inventory by adding newly commercialized chemicals that are reported to the Agency via the submission of Notices of Commencement of Manufacture/Import. Since the amendment of TSCA in 2016, existing chemicals on the Inventory are also updated regarding their commercial activity status via the submission of Notices of Activity.

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