This Small Business Sources Sought Notice is for information and planning purposes only and shall not be construed as a solicitation or as an obligation or commitment by the Government. This notice is intended strictly for Market Research. The National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases is conducting a market survey to determine the availability and technical capability of qualified small business, veteran-owned small business, service-disabled veteran-owned small business or HUBZone small businesses capable of providing Stability and metabolism of this compound in blood of 3 species (rat, dog and human).

A major research goal of the NIDDK to discover/develop small, "drug-like" molecules that are
agonists of the thyrotropin (thyroid-stimulating hormone, TSH) receptor (TSH-R) to be used as probes for TSH-R function. Under the Molecular Libraries Probe Production Centers Network (MLPCN) known drug or drug-like compounds were screened for activity at this receptor. The ultimate goal was to identify a lead compound for eventual use as a drug to diagnose and treat patients with thyroid cancer. Using a high-throughput screen, we discovered a successful probe that is a TSH-R agonist and have tested over 100 analogs of this active compound. Development of a lead drug candidate has progressed to the point that the lab now has an active pharmaceutical ingredient (API) that is a highly efficacious, highly potent TSH-R agonist in vitro. To be able to move this API forward for use in vivo in animal models and to obtain sufficient data to submit an application to the Food and Drug Administration for an investigational New Drug, we need to continue development.

It is anticipated that the actual work will take approximately 2 months from receipt of materials from NIDDK.

The intended procurement will be classified under North American Industrial Classification (NAICS) code 541712 with a size standard of 500. All respondents are requested to identify their firm's size and type of business. Interested firms responding to this market survey must provide (a) capability statement demonstrating their experience, skills and capability to fulfill the Government's requirements for the above. The capability statement shall be in sufficient enough detail, but not to exceed 15 pages, so that the Government can determine the experience and capability of your firm to provide the requirements above. Your capability statement, not to exceed 15 pages, should include references. Capability statement must be received at the email address identified in this synopsis by no later than 10 days (11:00 A.M. local time) on July 28, 2016. Any questions regarding this announcement must be sent via email to [email protected] and must include solicitation NICHD16109 in the subject line of email.

This synopsis is for information and planning purposes and is not to be construed as a commitment by the Government, nor will the Government pay for information solicited. Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provided feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate response to a solicitation.

Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provided feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate response to a solicitation. Confidentiality - No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s)." PLEASE NOTE: In order to receive an award, contractor must be registered and have valid certification in the System For Award Management (SAM) http://www.sam.gov

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