This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation and a separate written solicitation will not be issued. This solicitation number is NICHD16109 and is issued as a Request for Quotation (RFQ). The solicitation /contract will include all applicable provisions and clauses in effect through Federal Acquisition Circular 2005-87. The North American Industry Classification (NAICS) Code is code 541712 with a size standard of 500. This acquisition is being conducted using Simplified Acquisition Procedures in accordance with FAR Part 13. The National Institutes of Health (NIH), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) has a requirement to procure Stability and metabolism of this compound in blood of 3 species (rat, dog and human).

A major research goal of the NIDDK to discover/develop small, "drug-like" molecules that are agonists of the thyrotropin (thyroid-stimulating hormone, TSH) receptor (TSH-R) to be used as probes for TSH-R function. Under the Molecular Libraries Probe Production Centers Network (MLPCN) known drug or drug-like compounds were screened for activity at this receptor. The ultimate goal was to identify a lead compound for eventual use as a drug to diagnose and treat patients with thyroid cancer. Using a high-throughput screen, we discovered a successful probe that is a TSH-R agonist and have tested over 100 analogs of this active compound. Development of a lead drug candidate has progressed to the point that the lab now has an active pharmaceutical ingredient (API) that is a highly efficacious, highly potent TSH-R agonist in vitro. To be able to move this API forward for use in vivo in animal models and to obtain sufficient data to submit an application to the Food and Drug Administration for an investigational New Drug, we need to continue development. It is anticipated that the actual work will take approximately 2 months from receipt of materials from NIDDK.

The offeror must include a completed copy of the following provisions: 1) FAR Clause 52.212-1 Instructions to Offerors - Commercial items; 2) FAR Clause 52.212-2, Evaluation - Commercial Items. As stated in FAR Clause 52.212-2 (a) The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation will be advantageous to the Government, price and other factors considered. The following factors will be used equally to evaluate offers: Technical Evaluation, Price, and Past Performance.

Note: Past Performance Information: Vendors must submit a listing of the most recent contracts/awards (minimum of 3) which demonstrate similar work in nature to this Solicitation. Contracts/awards may include those entered with the Federal Government, state and local governments and commercial concerns. Include the following information for each contract or subcontract:

1. Name of Contracting Organization
2. Contract Number (for subcontracts provide the prime contract number and the subcontract number)
3. Contract Type
4. Total Contract Value
5. Description of Requirement
6. Contracting Officer's Name and Telephone Number
7. Program Manager's Name and Telephone Number

3) FAR Clause 52.212-3, Offeror Representations and Certifications - Commercial Items; 4) FAR Clause 52.212-4, Contract Terms and Conditions - Commercial Items; 5) FAR Clause 52-212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial Items - Deviation for Simplified Acquisitions. The Dun and Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN) and the certification of business size shall be included. The clauses are available in full text at http://www.arnet.gov/far.

PLEASE NOTE: In order to receive an award, contractor must be registered and have valid certification in the System For Award Management (SAM) http://www.sam.gov

Interested vendors capable of providing the Government with the items specified in this synopsis should submit their quotation to the below address. Quotations will be due on August 12, 2016 at 11:00 a.m. EST. Offerors shall provide an original and one copy of your quotation. The quotation must reference Solicitation number NICHD16109 All responsible sources may submit a quotation, which if timely received, shall be considered by the agency. Quotations must be submitted by email to [email protected] .

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