Questions and answers 1) Sections i-iv state: 'The monkeys will be lightly sedated with ketamine (10 - 20 mg/kg, im) for the 0 time blood and urine sample collection and treatment. ' Can the 0 time urine sample be acquired before sedation of the animal? Response-yes 2) Sections i-iv state: 'The subjects will be kept in a metabolism cage for the first 8 hours after treatment for collection of urine. At the 24 hour sample collection time, the animals will be kept in the metabolism cage for sufficient time to collect a urine sample. ' Therfore, are urine samples only to be collected 3 times - at 0 hours, 8 hours (total urine output from dosing time to 8 hours), and at 24 hours? Response-two urine samples 0-8 h and 24 h

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