The requested Tunable Femtosecond Laser System for the DBP is a critical FSL tool for developing and performing laser radiation safety evaluation of FDA regulated and emerging medical technology and products including FSL sources. This is a key equipment for accomplishing research goals and milestones associated with the research projects on laser radiation safety evaluation of the ongoing OSEL Research Program on Laser and Optical Radiation Safety (LORS) evaluation.

These projects are focused on addressing safety concerns and unmet public health needs for quantitative evaluation of potential laser radiation hazards posed by femtosecond laser-tissue interactions in multiphoton imaging and therapeutic ultrashort laser-based technologies and medical products. The requested tunable FSL system will provide a tunable FSL spectral range including specific laser wavelengths required for safety evaluation in two-photon imaging and therapeutic applications. Moreover, the FSL system will provide also a high-power green laser source that can be used as a pumping source of an existing FSL system.

Amendment 0001 to FDA-RFQ-112142, details of ammendent are in the attachment:

The purpose of this Amendment 0001 is to do the following:

1. To provide final responses to the questions received for the RFQ as part of the amendment.
2. To amend the following sections of the RFQ:

All other terms and conditions outlined in the RFQ remain unchanged.  No further questions will be answered.