The National Institute of Neurological Disorders and Stroke (NINDS), has initiated an effort to study Post-Infectious Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (PI-ME/CFS). This disorder refers to chronic and disabling fatigue, inability to recover after exercise, and physical and emotional discomfort occurring after a person has an infection. Protocol 16-N-0058 (Myalgic Encephalomyelitis/Chronic Fatigue Syndrome at the NIH) requires a dedicated portable EEG system that can operate in a variety of settings, has optimal performance characteristics, is stable for performance, is efficient to set up, and is comfortable for participants to wear for extended periods of time. The EEG unit must be able to measure several physiological variables simultaneously (i.e. EMG, respiration, EOG). The EEG unit must be able to work with both wired and wireless applications without affecting other features of the unit. The EEG unit will be used during the protocol's TMS procedures. TMS pulses temporarily interfere with EEG measurements. Diminishing the time between the TMS pulse and the ability to acquire EEG measurements is a priority for the protocol. The requested unit recovers after a TMS pulse within under 1 ms without the need to block the amplifier, which is the quickest recovery time from TMS pulses of EEG units available in the market. Active electrodes substantially improve
the quality of data and increase the efficiency and comfort of experimental set-up, which is of key importance in studying the ME/CFS population.

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