This is a presoliciation notice of pending Request for Proposal. 

The contractor shall provide analytical services of blood (plasma/serum), urine, saliva, fecal, and tissue samples for metabolomics analyses as defined herein. Samples will be provided by USARIEM.

The contractor shall be capable of conducting targeted and untargeted metabolite analyses at the following quantities:

1. Untargeted metabolomics analysis in up to 2000 plasma/serum samples in the contract base period and option period 1; up to 1500 plasma/serum samples in option period 2, and then up to 1000 plasma/serum samples per year thereafter.
2. Untargeted metabolomics analysis in up to 200 fecal samples per year.
3. Untargeted metabolomics analysis in up to 200 urine samples per year.
4. Untargeted metabolomics analysis in up to 200 saliva samples per year.
5. Untargeted metabolomics analysis in up to 100 tissue samples per year.

The contractor shall maintain an extensive library of >4,000 known metabolites and be able to accurately identify >1,000 metabolites in a sample.

The contractor laboratory shall be capable of the following:

1. Possess expertise in utilizing ultra-high performance liquid chromatography/tandem high resolution/accurate mass spectrometry for identifying metabolites in biological samples across multiple chemical classes.
2. Possess expertise in bioinformatics and pathway analysis of metabolomics data.
3. Laboratory systems are governed by a set of Standard Operating Procedures that are reviewed and updated, and which include quality control steps.
4. A documented history of contributing to peer-reviewed publications using metabolomics analyses.

The contractor shall analyze, summarize, and interpret generated metabolomics data for all samples. Data analysis will include, but not be limited to, a list of biochemicals detected, KEGG/HMBD links, relative quantitation, heat map and statistical results (i.e., detected biochemicals grouped by pathway and super-pathway, fold-change relative to comparator group, and associated statistical analyses, and summary of results).  Access to scientists that can assist in data analysis, interpretation and reporting shall also be included.