RFP S10-028. PROPOSALS MUST BE RECEIVED BY 3:00 P.M., Eastern Daylight Time, September 29, 2009. It is the Offerors responsibility to ensure that proposals are delivered by the due date and time required. Late proposals will not be accepted.

All questions or requests for clarifications must be e-mailed (No telephone calls accepted) to Matthew DeSantis at [email protected], or by facsimile at 301-228-4037 by 3:00 P.M., Eastern Daylight Time, September 15, 2009. Questions or requests directed to any other individual or outside the directives of this Solicitation will not be considered valid, nor will there be a response provided.

SAIC-Frederick, Inc., on behalf of the The National Cancer Institute, NCI, is seeking
offerors to submit proposals for nanotherapeutics that are in the post-optimization phase of the development cycle, and require evaluation in appropriate preclinical animal models of the disease for determination of both efficacy and safety profiles of the nanodevice and the targeted chemotherapeutic payload.

The purpose of this Request for Proposals (RFP) is to identify and evaluate the potential of candidate nanotechnologies to improve the bioavailability, solubility, pharmacokinetics, or therapeutic index of a range of drugs that would otherwise fail as anti-cancer agents. The NCI Alliance for Nanotechnology is interested in identifying these technologies at academic institutions, nanotechnology-focused pharmaceutical companies, and biotechnology companies.This acquisition shall be conducted in a two-Phase approach.

Once received, all proposals will be evaluated on the basis of technical merit, and a decision will be made to select a minimum of one, and possibly multiple awards.Specifics are outlined in detail in the attached Request for Proposals, S10-028.