This notice is a Notice of Intent. The Government intends to negotiate on a sole source basis with Taconic Farms/Artemis for the Generation of One X-Chromosomal Constitutive Knock In with Conditional Knock Out Mouse Model. This acquisition will be made in accordance with the format in Federal Acquisition Regulation (FAR) Subpart 12.6 "Streamlined Procedures for Evaluation and solicitation for commercial Items," as applicable, and as supplemented with additional information included in this notice. This announcement constitutes the only notice; quotes are not being requested and a written solicitation will not be issued. Submit offers on NOI-RML6-14032.

This acquisition is a Notice of Intent (NOI). The solicitation documents and incorporated provisions and clauses are those in effect through Federal Acquisition Circular (FAC)2005-76 July 25, 2014.
The North American Industry Classification System (NAICS) code for this procurement is (112990) with a small business size standard of $750,000. This requirement is not set aside for small business.
The National Institute of Allergy and Infectious Diseases (NIAID), Laboratory of Host Defense, is seeking to purchase the following Constitutive Knock In (KI) with Conditional Knockout (KO) allows site-specific insertion of DNA sequence or point mutations, combined with the possibility to eliminate the function of the target gene in a tissue-specific and/or inducible manner when combined with the appropriate Cre expressing mouse line. Taconic and its affiliate TaconicArtemis will conduct the following steps for generation of
one (1) X-linked Il13ra2 Constitutive Knock In with Conditional Knock Out Mouse Model:
a) Constitutive Knock In with Conditional Knock Out targeting vector construction and DNA
sequencing
b) Transfection of vector into selected cells
c) Isolation of targeted ES cell clones and molecular validation by Southern analysis with external and internal probes
d) Deletion of the selection marker(s) in selected targeted ES cells
e) Injection of targeted ES cells into diploid blastocysts
f) Chimera generation
g) Crossbreeding of chimeras with Tac mice to generate mice heterozygous for the Conditional Knock Out allele.
All shipping/handling charges must be quoted upfront.
FOB Point shall be Destination; Bethesda, MD 20892.

Place of Performance:
NIH/NIAID
Bethesda, MD 20892
United States

Award will be based on the capability of the item offered to meet the above stated salient characteristics, price, past performance, delivery, warranty, and the best value to the government.

The following FAR provisions apply to this acquisition:
52.212-1 Instructions to Offerors Commercial Items (April 2014)
FAR 52.213-3 Offerors Representations and Certifications - Commercial Items (April 2014)
Offerors must complete annual representations and certifications on-line at http://www.sam.gov in accordance with FAR 52.212-3 Offerors Representations and Certifications- Commercial Items
The following contract clauses apply to this acquisition:
FAR 52-212-4 Contract Terms and Conditions Commercial Items (May 2014)
FAR 52-212.5 Contract Terms and Conditions Required to Implement Statutes or Executive Orders Commercial Items (July 2014)

The applicable subparagraphs of FAR52.212-5 are included in the attachment to this posting.

Copies of the above-referenced provisions and clauses are available from http://www.acquisition.gov/far/loadmainre.html or, upon request, either by telephone or fax.

By submission of an offer, the offeror acknowledges the requirement that a prospective awardee shall be registered in the System for Award Management (SAM) database prior to award, during performance, and through final payment of any contract, basic agreement, basic ordering agreement, or blanket purchasing agreement resulting from this solicitation (www.sam.gov).

Copies of the above-referenced provisions and clauses are available from http://www.acquisition.gov/far/loadmainre.html or, upon request, either by telephone or fax.

This is an open-market Notice of Intent for the Purchase of Taconic Farms Generation of one X-Chromosomal Constitutive Knock In with Conditional Knock out Mouse Model as defined herein. The government intends to award a purchase order as a result of this notice that will include the terms and conditions set forth herein. To facilitate the award process all quotes must include a statement regarding the terms and conditions herein as follows:
"The Terms and conditions in the notice are acceptable to be included in the award document without modification, deletion or addition."
OR
"The terms and conditions in the notice are acceptable to be included in the award document with the exception, deletion, or addition of the following:"
(Quoter shall list exception(s) and rationale for the exception(s).)
Submission shall be received not later than 9/11/2014 at 4:30PM MST.

Offers may be mailed, e-mailed or faxed to Michael Barrett; (Fax - 406-363-9288), (E-Mail/ [email protected]). Late submissions shall be treated in accordance with the solicitation provision at FAR 52.212-1(f)

All responsible sources may submit an offer that will be considered by this Agency.
Any questions or concerns regarding this solicitation should be forwarded in writing via e-mail to Michael Barrett at [email protected].

Bid Protests Not Available