This is a Notice of Intent, not a request for proposal. The National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH) intends to negotiate on an other than full and open competition basis with Synthego to purchase gene editing services. Synthego is the only provider of the GMP-like material. This request will allow continuation of ongoing research within the LCIM. For consistency of results and data analysis, and to allow for valid comparisons between past and future experiments, the same GMP-like material must be used:

1. Sequence 1 Label: GP91phox CRISPRevolution mod-sgRNA, GMP-Like; Analytical HPLC; Bioburden (Aerobes, Yeast, Mold) - Method Suitability; Bioburden (Aerobes, Yeast, Mold) Test; Endotoxin - Method Suitability; Endotoxin Test; Custom QC Documents; S/H
2. Sequence 2 Label: MagT1 CRISPRevolution mod-sgRNA, GMP-Like; Analytical HPLC; Bioburden (Aerobes, Yeast, Mold) - Method Suitability; Bioburden (Aerobes, Yeast, Mold) Test; Endotoxin - Method Suitability; Endotoxin Test; Custom QC Documents; S/H
3. Sequence 3 Label: CGD CRISPRevolution mod-sgRNA, GMP-Like; Analytical HPLC; Bioburden (Aerobes, Yeast, Mold) - Method Suitability; Bioburden (Aerobes, Yeast, Mold) Test; Endotoxin - Method Suitability; Endotoxin Test; Custom QC Documents; S/H
4. Sequence 4 Label: SCID CRISPRevolution mod-sgRNA, GMP-Like; Analytical HPLC; Bioburden (Aerobes, Yeast, Mold) - Method Suitability; Bioburden (Aerobes, Yeast, Mold) Test; Endotoxin - Method Suitability; Endotoxin Test; Custom QC Documents; S/H

The statutory authority for this sole source requirement is 41 U.S.C. 1901(e)(2) as implemented by FAR 13.106-1 only one responsible source and no other supply of service will satisfy agency requirements. THIS IS NOT A REQUEST FOR PROPOSAL. All responsible sources that could provide comparable services may submit a capability statement that will be considered by email (subject line to reference NOI-NIAID-1981301_2) to Bevin Feutrier at [email protected] or to Ryan Richards at [email protected] by 8:00 am eastern standard time August 23, 2019. All responses received by the closing date of this synopsis will be considered by the Government. A determination not to compete this requirement, based upon responses to this notice, is solely within the discretion of the Government.

 

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