TITLE: Sources Sought Notice FDA SS-1161856
This is a SOURCES SOUGHT NOTICE to determine the availability of potential small businesses (e.g., 8(a), service-disabled veteran owned small business, HUBZone small business, small disadvantaged business, veteran-owned small business, and women-owned small business) in accordance with FAR 7.104(d). The potential small business will need to demonstrate the capability to perform all facets of the work described below.
The sole intent of this Sources Sought Notice is to obtain capabilities for set-aside and procurement planning purposes. The North American Industry Classification System (NAICS) code for the proposed acquisition is 334516, Analytical Laboratory Instrument Manufacturing, with a small business size standard of 500 employees. This is not an invitation for bid, request for proposal, or other solicitation, and in no way obligates the Food and Drug Administration (FDA) to award a contract.
BACKGROUND:
The Food and Drug Administration's Office of Acquisitions and Grants Services have a requirement for Fragment Analyzer to accurately assess the quality of the large fragment smears for the PacBio® library preparations. By using the Fragment Analyzer to QC our genomic DNA or RNA samples during our NGS library prep, we will have more consistency and reproducibility in our sequencing in house. Advanced Analytical worked closely together with Pacific Bioscience to validate their protocol according to the needs for the pacbio 30kb library preparation protocol.
Technical specifications for an instrument system for the quantification and sizing of DNA to including full integration capabilities with Pacific Biosystems sequencer RSII.

The DNA quantification and sizing system shall meet the following specifications:
The system shall be able to reliable assess large DNA fragments for sequencing (75bp to 50000bp).

Minimum product features shall include accurate qualification and quantification of nucleic acid (DNA or RNA) samples that have been fragmented or sheared, tailed, ligated with modified oligonucleotide, size selected, captured, released and amplified.

The system shall perform all analytical functions are automated via microfluidics control including sample delivery, sample injection, electrophoretic separation, staining and de-staining, fluorescence detection, data analysis and display, printing and archiving

Maximum capacity:For now 12 cap but we could upgrade it up to 48 or 96 cap
Minimum sample volume:20 µl (with 2 µl of sample typically required for dilution)
Resolution: As low as 3 bp (gel dependent)
Sizing accuracy:Typically 5% or better, size dependent
Sensitivity: 50 pg/µl for smears, <50 pg/µl for fragments
Light source power: One 1,000 mW LED
LED wavelength:470 nm
Emission collection devise: CCD detector

Please provide the follow Business information:
1. DUNS Number
2. Company Name
3. Company Address.
4. Company Point of Contact, phone number and email address
5. Type of company under NAICS, as validated via the System for Award Management (SAM). Additional information on NAICS codes can be found at www.sba.gov. Any potential government contract shall be registered on the SAM located at http://www.sam.gov/index.asp.
6. Corporate structure (corporation, LLC, sole proprietorship, partnership, limited liability partnership, professional corporation, etc.);
7. Current GSA Schedules appropriate to this Sources Sought
8. Current Government Wide Agency Contracts (GWACs)
9. Point of Contact, phone number and email address of individuals who can verify the demonstrated capabilities identified in the responses.

Interested parties having the capabilities necessary to provide the stated requirements may submit capability statements via email or regular mail to the point of contact listed below.
Responses shall be received not later than 10:00 AM EST, April 11, 2016. Capability statements will not be returned and will not be accepted after the due date.
Documentation should be emailed to: [email protected] with subject line titled "Sources Sought 1164608".

Bid Protests Not Available