The accessories for our DASbox micro-fermentation system will be used in support of ongoing research at the Laboratory of Malaria Immunology and Vaccinology (LMIV) to research, pursue, produce and clinical trial malaria vaccines. Place of Performance is Rockville, MD 20852.

The DasBox allows staff to perform Design of Experiments on various fermentation parameters to optimize the fermentation conditions at small scale before testing at larger scales. This system is a direct transfer to the BioFlo 320 fermentations system already in place. This system has excellent scalability and reproducibility; supports industry standard glass bioreactors and single use reactors; small working volumes saves money on reagents and cell starting volumes; very compact system using little benchtop space; individual temperature controls with liquid free heating and cooling; liquid free peltier exhaust condenser with easy handling by automatic slide in activation and slide out deactivation modes; LC display with key process parameters and integrated alarm functions; fully mass flow controlled for gas mixing of air, oxygen, nitrogen and carbon dioxide; standard sensors for precise measurements of temperature, pH, DO, and redox potential; precise miniature variable speed pumps with continuous flow rates down to 0.3 ml/h; sealed magnetic overhead drives for single use vessels and direct overhead drives for glass vessels - up - and down-flow selectable; can be used for process development, media optimization and Design of Experiments. This expansion will allow LMIV staff to create larger
micro scale experiments to find the best parameters
Accessory List:

76DXMP8 DX Multi Pump Module MP8
76DGTRIP Extra Triple Port Pg13.5
76DXFL05P11 DX Feedlines MP8 PTFE ID0.5
76SR0250ODLS DASbox® Vessel Type SR0250ODLS, 2x Rushton-type impeller, 60 - 250 mL, overhead drive
78108023 DO Sensor, Hamilton®, autoclavable, O.D. 12 mm, L 120 mm
78103205 pH Sensor, Hamilton® EasyFerm Plus, autoclavable, O.D. 12 mm, L 120 mm
76DXLVL DX Level Sensor with Compression Fitting

The statutory authority for this sole source requirement is 41 U.S.C. 253 (c) (1) as implemented by FAR 6.302-1 only one responsible source and no other supply of service will satisfy agency requirements. THIS IS NOT A REQUEST FOR PROPOSAL. All responsible sources that could provide comparable services may submit a capability statement that will be considered by email (subject line to reference NOI-NIAID-1936422) to Skye Duffner at [email protected] by 5:00 pm eastern standard time Wednesday, December 26, 2018. All responses received by the closing date of this synopsis will be considered by the Government. A determination not to compete this requirement, based upon responses to this notice, is solely within the discretion of the Government.