PRE-SOLICITATION NOTICE OF INTENT

NON-COMPETITIVE

INTRODUCTION

PURSUANT TO FAR Subpart 5.2—Synopses of Proposed Contract Actions, THIS IS A PRE-SOLICITATION NOTICE OF A PROPOSED CONTRACT TO ACTION.   

THIS IS A PRE-SOLICITATION NON-COMPETITIVE NOTICE OF INTENT TO AWARD A CONTRACT OR PURCHASE ORDER WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME). 

The National Institute on Drug Abuse (NIDA), Office of Acquisitions on behalf of the National Center for Advancing Translational Sciences intends to solicit by a request for quotation from Synthego for award on or around September 27, 2021. The purpose of this procurement is to purchase custom knockin cell lines for the Functional Genomics Lab.

NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE

The intended procurement is classified under NAICS code 541714 with a Size Standard of 1,000 employees.

REGULATORY AUTHORITY

The resultant contract will include all applicable provisions and clauses of the Federal Acquisition Regulation (FAR) in effect through the Federal Acquisition Circular (FAC) 2021-07.

STATUTORY AUTHORITY

This acquisition is conducted as non-competitive under the authority of 41 U.S.C. 253(c) under provisions of the statutory authority of FAR Subpart 6.302-1 – only one responsible source and no other supplies or services will satisfy agency requirements.

DESCRIPTION OF REQUIREMENT

Project Description

The National Institutes of Health has established an RNAi facility to provide intramural researchers with access to the equipment and expertise necessary to conduct genome-wide RNAi screens in mammalian cells. This facility works as a collaborative resource for doing RNAi assay development, screening, and initial follow up.  Our facility works with investigators to develop and optimize their assays for screening, conduct the screens and related informatics analyses, then performs follow-up screens on promising leads.  Further work is done with the PI to do the downstream biology required to get the quality publications and the kind of groundbreaking results needed.  This request is required for this facility to develop a flexible functional genomics platform that offers complementary and orthogonal CRISPR screens to NIH intramural investigators. Synethgo synthesizes state of the art clonal cell lines that follow the RNAi workflow closely. This item is needed to facilitate our RNAi screening program. This program is to provide intramural researchers with access to the equipment and expertise necessary to conduct large scale functional genomics screens.

Milestone 1a

Design and Synthesis of modified sgRNA and donor template (for knock-in projects).

Milestone 1b

Transfection and genotyping of the pool.

Milestone 2

Clonal isolation and initial genotyping

Milestone 3

Sequence validation of alleles

Level of Effort

2 vials each of two clones of edited cells at 0.5 x 10^6 cells/vial for adherent cells and 1 x 10^6 cells for suspension cells, containing the desired change as denoted above.

2 vials of Wild-Type Cells at 0.5-1 x 10^6 cells/vial.

Final project summary document.

Certificate of Analysis for the delivered cells, including mycoplasma data.

Period of Performance:

14 weeks after receipt of order

CLOSING STATEMENT

THIS SYNOPSIS IS NOT A REQUEST FOR COMPETITIVE PROPOSALS. However, interested parties may identify their interest and capability to respond to this notice.

An interested Offeror must be able to demonstrate its capabability to independently, and not as an agent of the Government, to provide the National Center for Advancing Translational Sciences (NCATS) with custom knockin cell lines for the Functional Genomics Lab.

Responses to this notice must include sufficient information to establish the interested parties’ bona-fide capabilities of providing the product or service.  The price quote shall include: unit price, list price, shipping and handling costs, delivery days after contract award, delivery terms, prompt payment discount terms, F.O.B. Point (Destination or Origin), product or catalog number(s); product description; and any other information or factors that may be considered in the award decision. Such factors may include: past performance; special features required for effective program performance; trade-in considerations; probable life of the item selected as compared with that of a comparable item; warranty considerations; maintenance availability; and environmental and energy efficiency considerations.

In addition the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov.”

A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government.  The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement.  

All responses must be received by September 20, 2021, 1:00 p.m. Eastern Time and must reference number 75N95021Q00426.

Responses must be submitted electronically to Llakim Dubroff, Contract Specialist at [email protected] and must reference the solicitation number 75N95021Q00426  on your electronic request.  FAX requests are not accepted.

“All responsible sources may submit a capability statement, proposal, or quotation, which shall be considered by the agency.