Concepts of Operation (CONOPS) and Use Case for physiological monitoring in the Air Force, DoD, and civilian sectors are broad and ever-expanding. The main drivers for this expansion are the substantial progress being made in the medical and performance monitoring community identifying key markers, and the technological advances of sensors and computing enabling realization of new devices. The need for reliable sensors to monitor and fuse biometric and biomarker data associated with human performance is the first step to developing a predictive model that would allow detection of predictive markers before actual degradation of performance in the warfighter is evident. The ability to simultaneously determine the levels of biomarkers along with biometrics such as ECG, HR, SpO2, NIBP, and/or respiration rates is a new paradigm in continuous performance monitoring. Combining biomarker data with biometrics results in a more accurate and complete predictive capability of human performance monitoring. A sensor device that can measure temperature, electrolytes glucose lactic acid, and multiple biomarkers such as Interleukin 6 (IL-6), Neuropeptide Y (NP-Y), and Cortisol is desired.

To date, the ability to continuously probe human bio-fluids, such as sweat, has shown limitations. In order to be useful as a means for performance monitoring, fluids would need to be continuously collected, prepared or processed in a manner to allow identification and measurement of suitable bio-markers, with the resultant measurement reported. Ultimately, this will likely be accomplished via microfluidic collection.

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