The National Institute of Environmental Health Sciences (NIEHS) is requesting information to determine the availability of interested parties to provide; 1) complete generation of transgenic mice by microinjection of DNA constructs; 2) provide conventional gene targeting services including ES cell electroporation and microinjection using targeting vectors; and 3) provide mouse maintenance, husbandry, health surveillance and assisted reproductive technologies as requested by NIEHS investigators. The contractor shall have an approved animal welfare assurance statement on file with the NIH Office of Laboratory Animal Welfare (OLAW). Accreditation of the facilities and program by the Association for the Assessment and Accreditation of Laboratory Animal Care, International (AAALAC) is required. For estimating purposes the Government anticipates a cost reimbursement completion type award with a period of performance of one base year and four one year options. IT IS EMPHASIZED THAT THIS NOTICE IS FOR PLANNING AND INFORMATION PURPOSES ONLY AND IS NOT TO BE CONSTRUED AS A COMMITMENT BY THE GOVERNMENT TO ENTER INTO A CONTRACTUAL AGREEMENT, NOR WILL THE GOVERNMENT PAY FOR INFORMATION SOLICITED. INTERESTED OFFERORS SHOULD SUBMIT (5) COPIES OF THEIR CAPABILITY STATEMENT NOT TO EXCEED FIFTEEN (15) PAGES IN LENGTH, EXCLUDING STANDARD BROCHURES, ETC., FOR RECEIPT BY THE AGENCY ON October 11, 2006. Please submit information to Patrick J. Barbour, Contract Specialist, NIEHS/OM/OA, P.O. Box 12874, Research Triangle Park, NC 27709. Courier address: Patrick J. Barbour, Contract Specialist, NIEHS/OM/OA, 79 TW Alexander Drive, Building 4401, Research Commons, Suite 100, Research Triangle Park, NC 27709 Inquiries will be accepted by fax (301) 451-5597 or e-mail [email protected]

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