Evaluation of Chemopreventive Agents by In Vivo Screening Assays The National Cancer Institute (NCI), Division of Cancer Prevention (DCP), Chemoprevention Development Group (CADRG), is interested in evaluating inhibitors or potential inhibitors of any stage of carcinogenesis, in order to identify potential chemopreventive agents against cancer. Such agents are to be further evaluated in appropriate toxicological or clinical settings. The CADRG has established a clearly defined integrated plan for evaluation of chemopreventive agents. This plan delineates detailed criteria for classifying the quantity and quality of information that currently exits on any chemopreventive agents and thus defines what additional information and investigations are required to qualify the agent's experimental use in intervention trials of human cancer. The primary purpose of this RFP is to evaluate chemopreventive agents In Vivo for inhibition carcinogenesis. The object of these studies is to establish the relative efficacies of selected chemopreventive agents in at least one animal model system. The animal model systems represent various groups elected target organs, different species, and different carcinogens. Those interested in obtaining a copy of this RFP should send their e-mail address to Aglae Cantave at [email protected] and a copy of the RFP will be forwarded electronically. AN AWARD WILL ONLY BE MADE TO A MASTER AGREEMENT HOLDER IN THE IN VIVO MASTER AGREEMENT POOL. The North American Industry Classification System (NAICS) code is 541710. Questions should be directed via facsimile or e-mail to Aglae Cantave, Contract Specialist, Prevention, Control Population Sciences Section, Research Contracts Branch, National Cancer Institute Bethesda Maryland, 20892-7195. Phone: (301) 496-6987; fax: (301) 402-8579; e-mail [email protected] NO COLLECT CALLS WILL BE ACCEPTED. Numbered Note 26: Based upon market research, the Government is not using the policies contained in Part 12, Acquisition of Commercial Items, in its solicitation for the described supplies or services. However, interested persons may identify to the Contracting Officer their interest and capability to satisfy the Government's requirement with commercial item within 15 days of this notice.

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