NAICS Code: 541710 The U.S. Environmental Protection Agency (U.S. EPA) has a requirement for preparation of permethrin enantiomers. Several methods of preparation of the enantiomers of permethrin are feasible and acceptable: 1) enantiomer separation by preparative HPLC, 2) enantioselective synthesis, 3) antibody or other biologically mediated preparations. Upon request, the EPA will provide the contractor with ~1g of permethrin for purification. Permethrin is composed of 2 isomers (cis- and trans-) and 4 enantiomers. Figure 1 shows the chemical structure of permethrin with chiral centers marked with an asterisk. Each isomer or enantiomer shall be of >90% optical purity. Each enantiomer shall be of >97% compound purity. The contractor shall provide a certificate of analysis for the two purity criteria that lists the method of determination, and also document the optical rotation of enantiomers with measurement conditions. Each separate enantiomer shall be identified as cis- or trans-permethrin, and the optical rotation (+ or -). NAICS Code 541710 applies with a small business size standard of 500 employees. The Request for Quote (RFQ) is expected to be issued approximately fifteen days after the date this notice is posted. Quotes will be due approximately 15 calendar days after issuance of the RFQ. The competitive small business set-aside has been dissolved and this procurement will now be full and open competition. The RFQ number is RFQ-RT-07-00112. The RFQ and any amendments will be available via the Internet http://www.epa.gov/oam/rtp_cmd. It will be your responsibility to frequently check the same site where the solicitation is posted for any amendments. All responsible small businesses may submit a RFQ which shall be considered by the Agency.

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