The National Institute of Allergy and Infectious Disease (NIAID) intends to negotiate, under the authority of 41 U.S.C. 253(c)(1) and FAR 6.302-1, a modification to its five (5) year Contract N01-AI-15447 with The Institute for Genomic Research for the Pathogen Functional Genomics Resource Center (PFGRC). The contract currently provides scientists with centralized resources necessary to conduct functional genomics studies on a variety of pathogens and vectors for which genomic sequence information is currently, or will soon be, available. The goals of the PFGRC are to provide microarrays, genotyping, clone access, bioinformatics, and repository support surrounded by a Center-Client web-based interface allowing easy access to resource acquisition, data and data analysis. The PFGRC is also developing and testing emerging genomic technologies and bioinformatics tools. The planned negotiated modification, which will provide for a level of increased effort over a period of three (3) years, (within the contract's current period) will provide for expanding current tasks such as producing and distributing microarrays, producing organism-specific DNA for the array (sequencing DNA and developing primers and PCR reactions), developing and evaluating emerging microarray technology and microbial genotyping methods, and increasing the database capacity and development of software tools for data analysis and display. The expansion will include increasing the number of arrays that will be available to the research community, including the number of arrays available for new organisms, especially organisms considered agents of bioterrorism and have the potential to cause emerging and re-emerging diseases. See Government Wide Numbered Note 22. No collect calls will be accepted.

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