The Centers for Disease Control and Prevention (CDC) intends to award, on a sole source basis, a purchase order to Biomind LLC. located in Bethesda, MD. The purchase order is for the purpose of performing these deliverables: supervised categorization analysis of the prior dataset, using Support Vector Machines, Genetic Programming and exponential regression methods, to learn models that differentiate CFS subjects from non-fatigued controls based on appropriate combinations of gene expression levels and clinical/epidemiologic information. Production of a written report summarizing the results of this analysis. Application of the models learned in Task 1 and the models learned during the analysis of the prior conventional core dataset, to the new dataset. This will provide a "true-out-of-sample" test of the validity of these models. Production of a written report summarizing the results of this analysis. Supervised categorization analysis of the new dataset, using Support Vector Machines, Genetic Programming and exponential regression methods, to learn models that differentiate CFS subjects from non-fatigued controls based on appropriate combinations of gene expression levels and clinical/epidemiologic information. Production of a written report summarizing the results of this analysis. The authority for this sole source procurement is FAR part 6.302-1 in that Biomind is the only known source with the knowledge required to provide this service. This is not a request for competitive proposals and no solicitation is available. Firms that believe they can provide the required services are encouraged to identify themselves and give written notification to the Contracting Officer within 15 days from the publication date of this synopsis. A determination by the Government not to compete this proposed action based on responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. Inquiries may be sent to Christine Dorsey by e-mail at [email protected] or by fax at 770-488-2668.

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