The Buffalo VAMC, Buffalo NY, Research Department has a requirement to purchase instrumentation capable of extracellular flux analysis, specifically, the Seahorse Bioscience XFe24 and XFeP Extracellular Flux Analyzers.. This is not a solicitation announcement. This is a sources sought synopsis only. The purpose of this synopsis is to gain knowledge of potential qualified sources and their size classification (large business, small business, 8(a), SDVOSB, etc.), relative to NAICS code 334516 (size standard of 500 employees). Responses to this synopsis will be used by the Government to make appropriate acquisition decisions. Based on responses to this synopsis, the Government may issue this RFQ as a Brand Name or Equal requirement in accordance with VAAR Clause 852.211-73, with Seahorse Bioscience as the Brand Name Manufacturer. The System includes the following specifications: System Description and Use The equipment brand name or equal to the XFe24 and XFeP Extracellular Flux Analyzers must be able to simultaneously interrogate the two major energy producing pathways of the cell - mitochondrial respiration and glycolysis - in a microplate in real-time. It must be able to determine in vitro oxygen consumption rate (OCR), and extracellular acidification rate (ECAR), in order to assess cellular functions such as oxidative phosphorylation, glycolysis, and fatty acid oxidation. The brand name or equal equipment must contain the following salient features: Brand Name or Equal Seahorse XFe24 Extracellular Flux Analyzer " Utilize a 96-well plate format (8 or 16 wells at a time) " Allows easy and quick assessment of small sample sets or limited amounts per sample, such as mitochondrial extracts from experimental animals or patient samples, making it convenient for pairwise comparisons, phenotyping, pilot experiments, iterative assay design and condition optimizing. " Have the capability to analyze metabolic pathways and cellular respiration within living cells or tissue extracts. Brand Name or Equal Seahorse XFe24 and XFeP Extracellular Flux Analyzers " Must be able to simultaneously interrogate the two major energy producing pathways of the cell - mitochondrial respiration and glycolysis - in a microplate in real-time. " Must be able to determine in vitro oxygen consumption rate (OCR), and extracellular acidification rate (ECAR), in order to assess cellular functions such as oxidative phosphorylation, glycolysis, and fatty acid oxidation. The vendor must be able to supply instrumentation to meet the following brand name or equal specifications: Seahorse Bioscience XFe24 Extracellular Flux Analyzer includes: " 102342-100 XFe24 FluxPak mini (2) " 103015-100 XF Cell Mito Stress Test Kit " 103020-100 XF Glycolysis Stress Test Kit " 102353-100 XF Base Medium " WARRANTY XFe24 Analyzer Warranty- 1 year " TRAINING XF Training, 2 days " 102342-100 XFe24 Installation Kit (FluxPak Mini) Seahorse Bioscience XFp Extracellular Flux Analyzer includes: " 103022-100 XFp FluxPak (2) " 103025-100 XFp Miniplates (1) " 103010-100 XFp Cell Mito Stress Test Kit (1) " 103017-100 XFp Glycolysis Stress Test Kit (1) " 103275-100 XFp Cell Energy Phenotype Test Kit(1) " 103057-100 Carrier Tray (pack of 4) " 103193-100 XFp Base Medium, 100 mL " INSTALLATION / TRAINING - 1 day on site install/ training " WARRANTY XFp Analyzer Depot Warranty- 1 year ? Delivery Information: Buffalo VAMC 3495 Bailey Avenue Buffalo, NY 14215 This notice is not a request for competitive proposals, however; any responsible source who believes it is capable of meeting the requirement may submit a capability statement to the contracting office no later than Monday, September 14, 2015 4:00PM, EST. Interest/capability statements may be sent to Elaine DiBucci at [email protected] and should include company name, address, point of contact, business size, and product information. No telephone responses will be accepted. This notice is to assist the Government in determining sources only. A solicitation is not currently available. If a solicitation is issued, all interested parties must respond to that solicitation announcement separately from the responses to this announcement.

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