The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals that leverage a novel understanding of the enteric nervous system as well as emerging neuromodulation technologies to selectively target neurons in the small intestine and alter the body’s stress response. The CoasterChase program aims to develop a multimodal, ingestible, sensing and stimulation platform for use in monitoring and modulating biomarkers of acute stress from within the small intestine. Proposed research should investigate innovative approaches that enable revolutionary advances in enteric neuromodulation and sensing, ingestible electronics, and modulation of the stress response. Specifically excluded is research that primarily results in evolutionary improvements to the existing state of practice.